Product Data Sheet
VU0483605
Catalog No. A61753
VU0483605 is a selective positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1). It demonstrates strong PAM activity with EC50 values of 390 nM in human and 356 nM in rat, indicating effective modulation across species. This compound is valuable for investigating the role of mGlu1 in neurological disorders and in studying synaptic plasticity and cognitive functions.
Chemical Information
| Catalog Num | A61753 |
|---|---|
| M. Wt | 446.67 |
| Formula | C20H10Cl3N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1623101-11-0 |
| Synonyms | |
| SMILES | O=C(C1=NC=CC=C1Cl)NC2=CC=C(N(C(C3=C4C=CC=C3Cl)=O)C4=O)C(Cl)=C2 |
Biological Activity
| Description | VU0483605 is a selective positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1). It demonstrates strong PAM activity with EC50 values of 390 nM in human and 356 nM in rat, indicating effective modulation across species. This compound is valuable for investigating the role of mGlu1 in neurological disorders and in studying synaptic plasticity and cognitive functions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
