Product Data Sheet
BMS-984923
Catalog No. A61754
BMS-984923 is a potent silent allosteric modulator (SAM) of the metabotropic glutamate receptor 5 (mGluR5), characterized by a high binding affinity (Ki = 0.6 nM). This compound effectively inhibits the interaction between PrPC and mGluR5, thereby preventing pathological signaling associated with amyloid-beta oligomers while preserving normal glutamate signaling. BMS-984923 is suitable for research applications related to neurodegenerative diseases and offers favorable pharmacokinetic properties, including enhanced oral bioavailability and the ability to cross the blood-brain barrier.
Chemical Information
| Catalog Num | A61754 |
|---|---|
| M. Wt | 374.82 |
| Formula | C22H15ClN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1375752-78-5 |
| Synonyms | |
| SMILES | O=C1O[C@H](C2=CC=CC=C2Cl)[C@@H](C3=CC(C#CC4=CC=CC=C4)=CN=C3)N1 |
Biological Activity
| Description | BMS-984923 is a potent silent allosteric modulator (SAM) of the metabotropic glutamate receptor 5 (mGluR5), characterized by a high binding affinity (Ki = 0.6 nM). This compound effectively inhibits the interaction between PrPC and mGluR5, thereby preventing pathological signaling associated with amyloid-beta oligomers while preserving normal glutamate signaling. BMS-984923 is suitable for research applications related to neurodegenerative diseases and offers favorable pharmacokinetic properties, including enhanced oral bioavailability and the ability to cross the blood-brain barrier. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
