Product Data Sheet
VU6001966
Catalog No. A61756
VU6001966 is a potent negative allosteric modulator of the metabotropic glutamate receptor 2 (mGlu2), exhibiting an IC50 of 78 nM, while demonstrating selectivity for mGlu2 over mGlu3 with an IC50 of >30 µM. This compound effectively crosses the blood-brain barrier, making it a valuable tool for neurological research. VU6001966 can also be utilized as a positron emission tomography (PET) tracer for studying mGlu2 dynamics, contributing to the understanding of glutamatergic signaling in various cognitive processes and neuropsychiatric disorders.
Chemical Information
| Catalog Num | A61756 |
|---|---|
| M. Wt | 326.33 |
| Formula | C17H15FN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2009052-76-8 |
| Synonyms | |
| SMILES | O=C(C1=NC=C(OCC2=NN(C)C=C2)C(C3=CC=C(F)C=C3)=C1)N |
Biological Activity
| Description | VU6001966 is a potent negative allosteric modulator of the metabotropic glutamate receptor 2 (mGlu2), exhibiting an IC50 of 78 nM, while demonstrating selectivity for mGlu2 over mGlu3 with an IC50 of >30 µM. This compound effectively crosses the blood-brain barrier, making it a valuable tool for neurological research. VU6001966 can also be utilized as a positron emission tomography (PET) tracer for studying mGlu2 dynamics, contributing to the understanding of glutamatergic signaling in various cognitive processes and neuropsychiatric disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
