Product Data Sheet
VU0360172
Catalog No. A61762
VU0360172 is a selective positive allosteric modulator of the mGlu5 receptor, exhibiting an EC50 of 16 nM and a Ki of 195 nM. It effectively stimulates polyphosphoinositide (PI) hydrolysis in vivo, an action that is absent in mice lacking the mGlu5 receptor gene. Additionally, VU0360172 features an alkyne group, facilitating its use as a click chemistry reagent that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various biochemical applications.
Chemical Information
| Catalog Num | A61762 |
|---|---|
| M. Wt | 294.32 |
| Formula | C18H15FN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1310012-12-4 |
| Synonyms | |
| SMILES | O=C(NC1CCC1)C2=CC=C(N=C2)C#CC3=CC=CC(F)=C3 |
Biological Activity
| Description | VU0360172 is a selective positive allosteric modulator of the mGlu5 receptor, exhibiting an EC50 of 16 nM and a Ki of 195 nM. It effectively stimulates polyphosphoinositide (PI) hydrolysis in vivo, an action that is absent in mice lacking the mGlu5 receptor gene. Additionally, VU0360172 features an alkyne group, facilitating its use as a click chemistry reagent that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various biochemical applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
