Product Data Sheet
JNJ-46281222
Catalog No. A61763
JNJ-46281222 is a highly potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGlu2, exhibiting nanomolar affinity with a Kd value of 1.7 nM. This compound shows significant modulatory potency, with a pEC50 value of 7.71. It serves as a valuable tool for research applications focused on neuropharmacology, particularly in the context of disorders related to glutamatergic signaling.
Chemical Information
| Catalog Num | A61763 |
|---|---|
| M. Wt | 414.47 |
| Formula | C23H25F3N4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1254980-38-5 |
| Synonyms | |
| SMILES | FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F |
Biological Activity
| Description | JNJ-46281222 is a highly potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGlu2, exhibiting nanomolar affinity with a Kd value of 1.7 nM. This compound shows significant modulatory potency, with a pEC50 value of 7.71. It serves as a valuable tool for research applications focused on neuropharmacology, particularly in the context of disorders related to glutamatergic signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
