Product Data Sheet
VU6004909
Catalog No. A61770
VU6004909 is a positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1), effectively crossing the blood-brain barrier. With EC50 values of 25.7 nM for human mGlu1 and 31 nM for rat mGlu1, it demonstrates significant modulation of receptor activity. VU6004909 has been shown to reduce dopamine release in the dorsolateral striatum in vivo, indicating potential applications in the treatment of psychotic disorders.
Chemical Information
| Catalog Num | A61770 |
|---|---|
| M. Wt | 378.35 |
| Formula | C21H15FN2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1860797-76-7 |
| Synonyms | |
| SMILES | O=C(C1=C(C)C=CO1)NC2=CC=C(N3C(C4=CC=C(C)C=C4C3=O)=O)C=C2F |
Biological Activity
| Description | VU6004909 is a positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1), effectively crossing the blood-brain barrier. With EC50 values of 25.7 nM for human mGlu1 and 31 nM for rat mGlu1, it demonstrates significant modulation of receptor activity. VU6004909 has been shown to reduce dopamine release in the dorsolateral striatum in vivo, indicating potential applications in the treatment of psychotic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
