Product Data Sheet
ML289
Catalog No. A61772
ML289 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 0.66 μM. This compound demonstrates over 15-fold selectivity for mGlu3 when compared to mGlu2 and shows no activity against mGlu5. Additionally, ML289 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications and research involving synaptic transmission and neurological disorders.
Chemical Information
| Catalog Num | A61772 |
|---|---|
| M. Wt | 349.42 |
| Formula | C22H23NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1382481-79-9 |
| Synonyms | VU0463597 |
| SMILES | O=C(N1C[C@H](CO)CCC1)C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2 |
Biological Activity
| Description | ML289 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 0.66 μM. This compound demonstrates over 15-fold selectivity for mGlu3 when compared to mGlu2 and shows no activity against mGlu5. Additionally, ML289 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications and research involving synaptic transmission and neurological disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
