Product Data Sheet
LY2389575 hydrochloride
Catalog No. A61789
LY2389575 hydrochloride is a selective noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 190 nM. This compound enhances Mrc1 levels while independently intensifying Amyloid beta (Aβ) toxicity. It serves as a valuable tool for investigations related to Alzheimer's disease and the underlying mechanisms of neurodegeneration.
Chemical Information
| Catalog Num | A61789 |
|---|---|
| M. Wt | 438.58 |
| Formula | C15H16BrCl3N4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 885104-09-6 |
| Synonyms | |
| SMILES | ClC1=CC=C(CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2)C(Cl)=C1.[H]Cl |
Biological Activity
| Description | LY2389575 hydrochloride is a selective noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 190 nM. This compound enhances Mrc1 levels while independently intensifying Amyloid beta (Aβ) toxicity. It serves as a valuable tool for investigations related to Alzheimer's disease and the underlying mechanisms of neurodegeneration. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
