Product Data Sheet
ML353
Catalog No. A61804
ML353 is a selective allosteric modulator targeting the metabotropic glutamate receptor 5 (mGlu5) with a Ki value of 18.2 nM. This compound enhances the affinity of common allosteric sites, demonstrating a 20-fold improvement over the previous mGlu5 SAM compound. ML353 is suitable for research applications aimed at elucidating the intrinsic activity of silent allosteric modulators in vivo or for use as an agent blocker. Additionally, as a click chemistry reagent featuring an alkyne group, ML353 can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
Chemical Information
| Catalog Num | A61804 |
|---|---|
| M. Wt | 306.33 |
| Formula | C19H15FN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2990506-75-5 |
| Synonyms | |
| SMILES | O=C(C1=NC=C(C#CC2=CC(F)=CC=C2)C=C1)N(C3)CC4C3C4 |
Biological Activity
| Description | ML353 is a selective allosteric modulator targeting the metabotropic glutamate receptor 5 (mGlu5) with a Ki value of 18.2 nM. This compound enhances the affinity of common allosteric sites, demonstrating a 20-fold improvement over the previous mGlu5 SAM compound. ML353 is suitable for research applications aimed at elucidating the intrinsic activity of silent allosteric modulators in vivo or for use as an agent blocker. Additionally, as a click chemistry reagent featuring an alkyne group, ML353 can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
