Product Data Sheet
MFZ 10-7
Catalog No. A61812
MFZ 10-7 is a highly potent and selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as an essential tool for investigating the pharmacological modulation of mGluR5 activity, particularly in studies of psychiatric and neurodegenerative disorders. Additionally, MFZ 10-7 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it suitable for applications in click chemistry.
Chemical Information
| Catalog Num | A61812 |
|---|---|
| M. Wt | 236.24 |
| Formula | C15H9FN2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1224431-15-5 |
| Synonyms | |
| SMILES | N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1 |
Biological Activity
| Description | MFZ 10-7 is a highly potent and selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as an essential tool for investigating the pharmacological modulation of mGluR5 activity, particularly in studies of psychiatric and neurodegenerative disorders. Additionally, MFZ 10-7 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it suitable for applications in click chemistry. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
