Product Data Sheet
VU-29
Catalog No. A61819
VU-29 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R), demonstrating an EC50 of 9 nM and a Ki of 244 nM for rat mGluR5. This compound exhibits remarkable selectivity for mGlu5R compared to other mGluR subtypes, with EC50 values of 557 nM and 1.5 μM for rat mGluR1 and rat mGluR2, respectively, and 154 nM for human mGluR4. VU-29 is valuable for research exploring mGlu5R modulation in neurological studies, potentially aiding in the understanding of mechanisms underlying various neuropsychiatric disorders.
Chemical Information
| Catalog Num | A61819 |
|---|---|
| M. Wt | 384.39 |
| Formula | C22H16N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 890764-36-0 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3)C4=CC=C([N+]([O-])=O)C=C4 |
Biological Activity
| Description | VU-29 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R), demonstrating an EC50 of 9 nM and a Ki of 244 nM for rat mGluR5. This compound exhibits remarkable selectivity for mGlu5R compared to other mGluR subtypes, with EC50 values of 557 nM and 1.5 μM for rat mGluR1 and rat mGluR2, respectively, and 154 nM for human mGluR4. VU-29 is valuable for research exploring mGlu5R modulation in neurological studies, potentially aiding in the understanding of mechanisms underlying various neuropsychiatric disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
