Product Data Sheet
VU0364770 hydrochloride
Catalog No. A61821
VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4). It demonstrates effective modulation with EC50 values of 290 nM for rat mGlu4 and 1.1 μM for human mGlu4, while also exhibiting antagonist activity against mGlu5 and PAM activity at mGlu6. Additionally, VU0364770 hydrochloride shows inhibition of monoamine oxidase with Ki values of 8.5 μM for human MAO-A and 0.72 μM for human MAO-B, making it valuable for research in neuropharmacology and related fields.
Chemical Information
| Catalog Num | A61821 |
|---|---|
| M. Wt | 269.13 |
| Formula | C12H10Cl2N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1414842-70-8 |
| Synonyms | |
| SMILES | O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2.[H]Cl |
Biological Activity
| Description | VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4). It demonstrates effective modulation with EC50 values of 290 nM for rat mGlu4 and 1.1 μM for human mGlu4, while also exhibiting antagonist activity against mGlu5 and PAM activity at mGlu6. Additionally, VU0364770 hydrochloride shows inhibition of monoamine oxidase with Ki values of 8.5 μM for human MAO-A and 0.72 μM for human MAO-B, making it valuable for research in neuropharmacology and related fields. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
