Product Data Sheet
YM-202074
Catalog No. A61833
YM-202074 is a selective allosteric antagonist of metabotropic glutamate receptor type 1 (mGluR1) with significant affinity, exhibiting a Ki value of 4.8 nM for rat mGluR1. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, with an IC50 of 8.6 nM. Additionally, YM-202074 demonstrates potent neuroprotective effects in transient middle cerebral artery occlusion rat models, making it a valuable tool for research in neuroprotection and glutamatergic signaling pathways.
Chemical Information
| Catalog Num | A61833 |
|---|---|
| M. Wt | 414.56 |
| Formula | C22H30N4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 299900-83-7 |
| Synonyms | |
| SMILES | O=C(N(C1CCCCC1)C)C2=CN3C4=C(C=CC(CN(CCOC)C)=C4)N=C3S2 |
Biological Activity
| Description | YM-202074 is a selective allosteric antagonist of metabotropic glutamate receptor type 1 (mGluR1) with significant affinity, exhibiting a Ki value of 4.8 nM for rat mGluR1. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, with an IC50 of 8.6 nM. Additionally, YM-202074 demonstrates potent neuroprotective effects in transient middle cerebral artery occlusion rat models, making it a valuable tool for research in neuroprotection and glutamatergic signaling pathways. |
|---|
RETURN POLICY
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
