Product Data Sheet
LY487379 hydrochloride
Catalog No. A61844
LY487379 hydrochloride is a selective positive allosteric modulator (PAM) of the human mGluR2 receptor. It enhances glutamate-stimulated [35S]GTPγS binding, exhibiting an EC50 value of 1.7 μM for mGluR2, and shows significantly lower activity at mGlu3 receptors. This compound has demonstrated potential in promoting cognitive flexibility and facilitating behavioral inhibition in rat models, making it a valuable reagent for schizophrenia research and the study of related neuropsychiatric disorders.
Chemical Information
| Catalog Num | A61844 |
|---|---|
| M. Wt | 488.91 |
| Formula | C21H20ClF3N2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 353229-59-1 |
| Synonyms | |
| SMILES | FC(F)(F)CS(=O)(N(C1=CC=C(OC2=CC=CC=C2OC)C=C1)CC3=CC=CN=C3)=O.[H]Cl |
Biological Activity
| Description | LY487379 hydrochloride is a selective positive allosteric modulator (PAM) of the human mGluR2 receptor. It enhances glutamate-stimulated [35S]GTPγS binding, exhibiting an EC50 value of 1.7 μM for mGluR2, and shows significantly lower activity at mGlu3 receptors. This compound has demonstrated potential in promoting cognitive flexibility and facilitating behavioral inhibition in rat models, making it a valuable reagent for schizophrenia research and the study of related neuropsychiatric disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
