Product Data Sheet
Basimglurant sulfate
Catalog No. A61855
Basimglurant sulfate is a selective negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). With a Ki of 1.4 nM, it effectively inhibits mGlu5-mediated signaling and receptor constitutive activity, impacting dopamine regulation in the nucleus accumbens. This compound demonstrates anxiolytic, antidepressant-like, analgesic, and arousal-promoting effects, while also influencing δ-wave power during non-rapid eye movement sleep. Basimglurant sulfate is valuable for research applications in areas such as depression, anxiety disorders, and fragile X syndrome.
Chemical Information
| Catalog Num | A61855 |
|---|---|
| M. Wt | 423.85 |
| Formula | C18H15ClFN3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1034442-21-1 |
| Synonyms | RG7090 sulfate; RO4917523 sulfate |
| SMILES | O=S(O)(O)=O.FC1=CC=C(N2C(C)=NC(C#CC3=CC(Cl)=NC=C3)=C2C)C=C1 |
Biological Activity
| Description | Basimglurant sulfate is a selective negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). With a Ki of 1.4 nM, it effectively inhibits mGlu5-mediated signaling and receptor constitutive activity, impacting dopamine regulation in the nucleus accumbens. This compound demonstrates anxiolytic, antidepressant-like, analgesic, and arousal-promoting effects, while also influencing δ-wave power during non-rapid eye movement sleep. Basimglurant sulfate is valuable for research applications in areas such as depression, anxiety disorders, and fragile X syndrome. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
