Product Data Sheet
MFZ 10-7 hydrochloride
Catalog No. A61865
MFZ 10-7 hydrochloride is a potent and selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as a valuable tool in neurological research, particularly for studies related to synaptic transmission and potential therapeutic approaches for neurodegenerative diseases. Furthermore, MFZ 10-7 hydrochloride features an alkyne group, enabling its use in click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules.
Chemical Information
| Catalog Num | A61865 |
|---|---|
| M. Wt | 272.70 |
| Formula | C15H10ClFN2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1779796-36-9 |
| Synonyms | |
| SMILES | N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1.[H]Cl |
Biological Activity
| Description | MFZ 10-7 hydrochloride is a potent and selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGluR5), exhibiting a Ki of 0.67 nM for rat mGluR5. This compound serves as a valuable tool in neurological research, particularly for studies related to synaptic transmission and potential therapeutic approaches for neurodegenerative diseases. Furthermore, MFZ 10-7 hydrochloride features an alkyne group, enabling its use in click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
