Product Data Sheet
TC-N 22A
Catalog No. A61867
TC-N 22A is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4), exhibiting an EC50 of 9 nM in human mGlu4-expressing BHK cells. This compound demonstrates minimal activity at other mGlu receptors (EC50 > 10 μM), including mGlu1, 2, 3, 5, and 7. TC-N 22A is suitable for in vivo research studies focused on central nervous system diseases, offering insights into mGlu4-mediated pathways.
Chemical Information
| Catalog Num | A61867 |
|---|---|
| M. Wt | 283.35 |
| Formula | C14H13N5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1314140-00-5 |
| Synonyms | |
| SMILES | C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1 |
Biological Activity
| Description | TC-N 22A is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4), exhibiting an EC50 of 9 nM in human mGlu4-expressing BHK cells. This compound demonstrates minimal activity at other mGlu receptors (EC50 > 10 μM), including mGlu1, 2, 3, 5, and 7. TC-N 22A is suitable for in vivo research studies focused on central nervous system diseases, offering insights into mGlu4-mediated pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
