Product Data Sheet
(±)-LY367385 (racemic)
Catalog No. A61872
(±)-LY367385 is a potent and selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). It inhibits quisqualate-induced phosphoinositide hydrolysis with an IC50 value of 8.8 μM, demonstrating significant selectivity over mGluR5a, which has an IC50 greater than 100 μM. This compound is utilized in research applications focused on neuronal signaling and the modulation of excitatory neurotransmission in neurological studies.
Chemical Information
| Catalog Num | A61872 |
|---|---|
| M. Wt | 209.20 |
| Formula | C10H11NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 198419-90-8 |
| Synonyms | |
| SMILES | O=C(O)C(N)C1=CC=C(C(O)=O)C=C1C |
Biological Activity
| Description | (±)-LY367385 is a potent and selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). It inhibits quisqualate-induced phosphoinositide hydrolysis with an IC50 value of 8.8 μM, demonstrating significant selectivity over mGluR5a, which has an IC50 greater than 100 μM. This compound is utilized in research applications focused on neuronal signaling and the modulation of excitatory neurotransmission in neurological studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
