Product Data Sheet
Ro 67-4853
Catalog No. A61874
Ro 67-4853 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an effective concentration (pEC50) of 7.16 for the rmGlu1a receptor. This compound interacts with the transmembrane domain of the receptor to enhance the potency of L-glutamate, thereby modulating group I mGlu receptors, including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 is useful in research applications focused on enhancing sensory synaptic responses, particularly in models involving repetitive vibrissa stimulation.
Chemical Information
| Catalog Num | A61874 |
|---|---|
| M. Wt | 325.36 |
| Formula | C19H19NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 302841-89-0 |
| Synonyms | |
| SMILES | CCCCOC(NC(C1C2=CC=CC=C2OC3=CC=CC=C13)=O)=O |
Biological Activity
| Description | Ro 67-4853 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an effective concentration (pEC50) of 7.16 for the rmGlu1a receptor. This compound interacts with the transmembrane domain of the receptor to enhance the potency of L-glutamate, thereby modulating group I mGlu receptors, including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 is useful in research applications focused on enhancing sensory synaptic responses, particularly in models involving repetitive vibrissa stimulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
