Product Data Sheet
R214127
Catalog No. A61886
R214127 is a selective antagonist of the mGlu1 receptor, exhibiting IC50 values of 6 nM for rat mGlu1a and 14 nM for human mGlu1a. This compound engages a site within the glutamate binding pocket, competing for the same transmembrane segment VII as other noncompetitive mGlu1 antagonists. R214127 is utilized in research applications focusing on neuromodulation and the elucidation of mGlu1 receptor functions in various physiological and pathological contexts.
Chemical Information
| Catalog Num | A61886 |
|---|---|
| M. Wt | 303.35 |
| Formula | C20H17NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 409345-76-2 |
| Synonyms | |
| SMILES | O=C(CC1=CC=CC=C1)C2=CC3=CC4=C(OCCC4)N=C3C=C2 |
Biological Activity
| Description | R214127 is a selective antagonist of the mGlu1 receptor, exhibiting IC50 values of 6 nM for rat mGlu1a and 14 nM for human mGlu1a. This compound engages a site within the glutamate binding pocket, competing for the same transmembrane segment VII as other noncompetitive mGlu1 antagonists. R214127 is utilized in research applications focusing on neuromodulation and the elucidation of mGlu1 receptor functions in various physiological and pathological contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
