Product Data Sheet
YM-202074 fumarate
Catalog No. A61899
YM-202074 fumarate is a selective allosteric antagonist of the metabotropic glutamate receptor type 1 (mGluR1), demonstrating high affinity with a Ki of 4.8 nM. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, exhibiting an IC50 of 8.6 nM. Additionally, YM-202074 fumarate exhibits potent neuroprotective effects in models of transient middle cerebral artery occlusion, making it a valuable tool for research on neuroprotection and mGluR1-related pathways.
Chemical Information
| Catalog Num | A61899 |
|---|---|
| M. Wt | 1177.34 |
| Formula | C56H72N8O16S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 299900-84-8 |
| Synonyms | |
| SMILES | OC(/C=C/C(O)=O)=O.CN(C1CCCCC1)C(C2=CN3C4=CC(CN(C)CCOC)=CC=C4N=C3S2)=O.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O.CN(C5CCCCC5)C(C6=CN7C8=CC(CN(C)CCOC)=CC=C8N=C7S6)=O |
Biological Activity
| Description | YM-202074 fumarate is a selective allosteric antagonist of the metabotropic glutamate receptor type 1 (mGluR1), demonstrating high affinity with a Ki of 4.8 nM. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, exhibiting an IC50 of 8.6 nM. Additionally, YM-202074 fumarate exhibits potent neuroprotective effects in models of transient middle cerebral artery occlusion, making it a valuable tool for research on neuroprotection and mGluR1-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
