Product Data Sheet
VU0477886
Catalog No. A61903
VU0477886 is a positive allosteric modulator of metabotropic glutamate receptor subtype 4 (mGlu4), demonstrating potent activation with an EC50 value of 95 nM and achieving 89% of maximal glutamate response. This compound exhibits favorable pharmacokinetic properties, with a brain-to-plasma distribution ratio (Kp) of 1.3, making it a suitable candidate for neurological research. VU0477886 has shown significant therapeutic effects in preclinical models of Parkinson's disease, highlighting its potential for the treatment of movement disorders.
Chemical Information
| Catalog Num | A61903 |
|---|---|
| M. Wt | 392.80 |
| Formula | C20H13ClN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1926222-30-1 |
| Synonyms | |
| SMILES | O=C(C1=NC=CC=C1N)NC2=CC=C(N3C(C4=C(C3=O)C=CC=C4)=O)C(Cl)=C2 |
Biological Activity
| Description | VU0477886 is a positive allosteric modulator of metabotropic glutamate receptor subtype 4 (mGlu4), demonstrating potent activation with an EC50 value of 95 nM and achieving 89% of maximal glutamate response. This compound exhibits favorable pharmacokinetic properties, with a brain-to-plasma distribution ratio (Kp) of 1.3, making it a suitable candidate for neurological research. VU0477886 has shown significant therapeutic effects in preclinical models of Parkinson's disease, highlighting its potential for the treatment of movement disorders. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
