Product Data Sheet
HexylHIBO
Catalog No. A61908
HexylHIBO is a selective antagonist of group I metabotropic glutamate receptors, specifically mGlu1a and mGlu5a, with dissociation constants (Kbs) of 140 μM and 110 μM, respectively. This compound has shown efficacy in reducing spontaneous excitatory postsynaptic currents (sEPSCs) in rat models. It does not inhibit mGlu2 and mGlu4a receptors, making it a valuable tool for investigating the role of group I mGluRs in neurological research and the pathophysiology of neuropsychiatric disorders.
Chemical Information
| Catalog Num | A61908 |
|---|---|
| M. Wt | 256.30 |
| Formula | C12H20N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 334887-43-3 |
| Synonyms | |
| SMILES | O=C(O)C(N)CC(ON1)=C(CCCCCC)C1=O |
Biological Activity
| Description | HexylHIBO is a selective antagonist of group I metabotropic glutamate receptors, specifically mGlu1a and mGlu5a, with dissociation constants (Kbs) of 140 μM and 110 μM, respectively. This compound has shown efficacy in reducing spontaneous excitatory postsynaptic currents (sEPSCs) in rat models. It does not inhibit mGlu2 and mGlu4a receptors, making it a valuable tool for investigating the role of group I mGluRs in neurological research and the pathophysiology of neuropsychiatric disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
