Product Data Sheet
YM-230888
Catalog No. A61921
YM-230888 is a selective allosteric antagonist of the metabotropic glutamate receptor 1 (mGlu1), exhibiting a binding affinity (Ki) of 13 nM. It effectively inhibits the production of inositol phosphates in rat cerebellar granule cells, with an IC50 of 13 nM. Research indicates that YM-230888 possesses significant antinociceptive effects in models of hyperalgesia induced by Streptozotocin, as well as in complete Freund's adjuvant-induced arthritis pain models, highlighting its potential utility in pain management studies.
Chemical Information
| Catalog Num | A61921 |
|---|---|
| M. Wt | 360.52 |
| Formula | C19H28N4OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 446257-23-4 |
| Synonyms | |
| SMILES | C1(NC2CCCCCC2)=C3C(SC(CNC[C@H]4CCCO4)=C3)=NC=N1 |
Biological Activity
| Description | YM-230888 is a selective allosteric antagonist of the metabotropic glutamate receptor 1 (mGlu1), exhibiting a binding affinity (Ki) of 13 nM. It effectively inhibits the production of inositol phosphates in rat cerebellar granule cells, with an IC50 of 13 nM. Research indicates that YM-230888 possesses significant antinociceptive effects in models of hyperalgesia induced by Streptozotocin, as well as in complete Freund's adjuvant-induced arthritis pain models, highlighting its potential utility in pain management studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
