Product Data Sheet
RO4988546
Catalog No. A61926
RO4988546 is a negative allosteric modulator (NAM) of metabotropic glutamate receptors 2 and 3 (mGlu2 and mGlu3). This compound decreases the binding affinity of [3H]-LY354740 at the receptor's positive allosteric site, which impacts G protein coupling and intracellular signaling pathways. RO4988546 is valuable for research in developing antidepressants and cognitive enhancers, offering insights into therapeutic mechanisms targeting glutamatergic signaling.
Chemical Information
| Catalog Num | A61926 |
|---|---|
| M. Wt | 512.38 |
| Formula | C21H10F6N4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 911114-85-7 |
| Synonyms | |
| SMILES | O=S(C1=CC(C#CC2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F)=CN=C1)(O)=O |
Biological Activity
| Description | RO4988546 is a negative allosteric modulator (NAM) of metabotropic glutamate receptors 2 and 3 (mGlu2 and mGlu3). This compound decreases the binding affinity of [3H]-LY354740 at the receptor's positive allosteric site, which impacts G protein coupling and intracellular signaling pathways. RO4988546 is valuable for research in developing antidepressants and cognitive enhancers, offering insights into therapeutic mechanisms targeting glutamatergic signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
