Product Data Sheet
LM11A-31
Catalog No. A61976
LM11A-31 is a non-peptide ligand targeting the p75 neurotrophin receptor (p75NTR) and functions as a potent antagonist of proNGF (nerve growth factor). This orally active amino acid derivative demonstrates high permeability across the blood-brain barrier and effectively inhibits p75-mediated neurodegeneration. Research indicates that LM11A-31 can reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease, particularly during mid- to late-stage disease progression, making it valuable for studying neurodegenerative conditions and developing therapeutic strategies.
Chemical Information
| Catalog Num | A61976 |
|---|---|
| M. Wt | 243.35 |
| Formula | C12H25N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 102562-74-3 |
| Synonyms | |
| SMILES | CC[C@H](C)[C@H](N)C(NCCN1CCOCC1)=O |
Biological Activity
| Description | LM11A-31 is a non-peptide ligand targeting the p75 neurotrophin receptor (p75NTR) and functions as a potent antagonist of proNGF (nerve growth factor). This orally active amino acid derivative demonstrates high permeability across the blood-brain barrier and effectively inhibits p75-mediated neurodegeneration. Research indicates that LM11A-31 can reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease, particularly during mid- to late-stage disease progression, making it valuable for studying neurodegenerative conditions and developing therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
