Product Data Sheet
L-733060 hydrochloride
Catalog No. A61977
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist that primarily targets pain transmission and neural plasticity. By inhibiting the binding of Substance P to the NK-1 receptor, L-733060 hydrochloride effectively blocks the enhancement of long-term potentiation (LTP) in the hippocampus. This compound has demonstrated the ability to reverse orofacial hyperalgesia induced by experimental occlusal interference in rat models. Additionally, L-733060 hydrochloride inhibits neurogenic plasma extravasation without adverse effects on cardiovascular function and may possess anti-tumor properties. It is suitable for exploring mechanisms of chronic orofacial pain.
Chemical Information
| Catalog Num | A61977 |
|---|---|
| M. Wt | 439.82 |
| Formula | C20H20ClF6NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 148687-76-7 |
| Synonyms | |
| SMILES | FC(F)(C1=CC(C(F)(F)F)=CC(CO[C@@H]2[C@@](C3=CC=CC=C3)([H])NCCC2)=C1)F.Cl |
Biological Activity
| Description | L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist that primarily targets pain transmission and neural plasticity. By inhibiting the binding of Substance P to the NK-1 receptor, L-733060 hydrochloride effectively blocks the enhancement of long-term potentiation (LTP) in the hippocampus. This compound has demonstrated the ability to reverse orofacial hyperalgesia induced by experimental occlusal interference in rat models. Additionally, L-733060 hydrochloride inhibits neurogenic plasma extravasation without adverse effects on cardiovascular function and may possess anti-tumor properties. It is suitable for exploring mechanisms of chronic orofacial pain. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
