Product Data Sheet
L-732138
Catalog No. A61978
L-732138 is a selective and potent antagonist of the neurokinin-1 (NK-1) receptor, exhibiting an IC50 of 2.3 nM. This compound demonstrates a 200-fold greater potency in cloned human NK-1 receptors compared to cloned rat NK-1 receptors, and is more than 1000-fold more selective than human NK-2 and NK-3 receptors. L-732138 is useful in research focused on pain modulation, particularly in the reduction of hyperalgesia, and has shown potential antitumor activity.
Chemical Information
| Catalog Num | A61978 |
|---|---|
| M. Wt | 472.38 |
| Formula | C22H18F6N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 148451-96-1 |
| Synonyms | |
| SMILES | O=C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@H](CC2=CNC3=CC=CC=C23)NC(C)=O |
Biological Activity
| Description | L-732138 is a selective and potent antagonist of the neurokinin-1 (NK-1) receptor, exhibiting an IC50 of 2.3 nM. This compound demonstrates a 200-fold greater potency in cloned human NK-1 receptors compared to cloned rat NK-1 receptors, and is more than 1000-fold more selective than human NK-2 and NK-3 receptors. L-732138 is useful in research focused on pain modulation, particularly in the reduction of hyperalgesia, and has shown potential antitumor activity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
