Product Data Sheet
Orvepitant maleate
Catalog No. A61981
Orvepitant maleate is a potent and selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting a pKi of 10.2 for the human receptor. This orally active compound effectively crosses the blood-brain barrier, making it a valuable tool in neurological research. Orvepitant maleate shows promise for therapeutic applications in depressive disorders and chronic refractory cough (CRC), providing insights into the modulation of neurokinin pathways.
Chemical Information
| Catalog Num | A61981 |
|---|---|
| M. Wt | 744.70 |
| Formula | C35H39F7N4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 579475-24-4 |
| Synonyms | GW823296 maleate |
| SMILES | O=C(N1[C@@H](C2=CC=C(F)C=C2C)C[C@@H](N3C[C@@](CCC4=O)([H])N4CC3)CC1)N([C@@H](C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)C)C.O=C(O)/C=C\C(O)=O |
Biological Activity
| Description | Orvepitant maleate is a potent and selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting a pKi of 10.2 for the human receptor. This orally active compound effectively crosses the blood-brain barrier, making it a valuable tool in neurological research. Orvepitant maleate shows promise for therapeutic applications in depressive disorders and chronic refractory cough (CRC), providing insights into the modulation of neurokinin pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
