Product Data Sheet
Rolapitant hydrochloride hydrate
Catalog No. A61993
Rolapitant hydrochloride hydrate is a potent and selective neurokinin 1 (NK1) receptor antagonist, exhibiting a Ki value of 0.66 nM. This compound is known for its long-acting and orally bioactive properties, making it suitable for therapeutic applications. Notably, Rolapitant hydrochloride hydrate demonstrates significant anti-emetic activity, as evidenced in ferret emesis models, supporting its potential use in managing nausea and vomiting. Additionally, it does not interact with CYP3A4, allowing for broader applicability in combination therapies.
Chemical Information
| Catalog Num | A61993 |
|---|---|
| M. Wt | 554.95 |
| Formula | C25H29ClF6N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 914462-92-3 |
| Synonyms | SCH619734 hydrochloride hydrate |
| SMILES | O=C1N[C@]2(CN[C@@](C3=CC=CC=C3)(CO[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)CC2)CC1.[H]Cl.O |
Biological Activity
| Description | Rolapitant hydrochloride hydrate is a potent and selective neurokinin 1 (NK1) receptor antagonist, exhibiting a Ki value of 0.66 nM. This compound is known for its long-acting and orally bioactive properties, making it suitable for therapeutic applications. Notably, Rolapitant hydrochloride hydrate demonstrates significant anti-emetic activity, as evidenced in ferret emesis models, supporting its potential use in managing nausea and vomiting. Additionally, it does not interact with CYP3A4, allowing for broader applicability in combination therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
