Product Data Sheet
SB 218795
Catalog No. A62015
SB 218795 is a selective non-peptide antagonist of the neurokinin-3 (NK3) receptor, exhibiting a Ki of 13 nM for human NK3 (hNK3). This compound demonstrates significant selectivity, being approximately 90-fold and 7000-fold more potent against hNK3 compared to human NK2 and NK1 receptors, respectively. Research applications include studying the role of NK3 receptors in neurobiology and investigating potential therapeutic targets for managing related disorders. Additionally, SB 218795 has been shown to inhibit NK3 receptor-mediated pupillary constriction in rabbits, presenting further opportunities for exploration in translational research.
Chemical Information
| Catalog Num | A62015 |
|---|---|
| M. Wt | 396.44 |
| Formula | C25H20N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 174635-53-1 |
| Synonyms | |
| SMILES | COC([C@@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=CC=C3)=NC4=CC=CC=C24)=O)=O |
Biological Activity
| Description | SB 218795 is a selective non-peptide antagonist of the neurokinin-3 (NK3) receptor, exhibiting a Ki of 13 nM for human NK3 (hNK3). This compound demonstrates significant selectivity, being approximately 90-fold and 7000-fold more potent against hNK3 compared to human NK2 and NK1 receptors, respectively. Research applications include studying the role of NK3 receptors in neurobiology and investigating potential therapeutic targets for managing related disorders. Additionally, SB 218795 has been shown to inhibit NK3 receptor-mediated pupillary constriction in rabbits, presenting further opportunities for exploration in translational research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
