Product Data Sheet
SB 235375
Catalog No. A62017
SB 235375 is a selective antagonist of the human neurokinin-3 (hNK-3) receptor, developed through structural optimization of 2-phenyl-4-quinolinecarboxylic acid amide. It exhibits high affinity specifically for the hNK-3 receptor, showing significantly lower binding to hNK-1 and hNK-2 receptors. In vitro, SB 235375 effectively inhibits NK-3 receptor-mediated contraction and calcium mobilization. Additionally, in vivo studies reveal its capability to attenuate NK-3 receptor-driven responses through both oral and intravenous administration in animal models. This makes SB 235375 a valuable tool for research in neurokinin signaling and related physiological processes.
Chemical Information
| Catalog Num | A62017 |
|---|---|
| M. Wt | 440.49 |
| Formula | C27H24N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 224961-34-6 |
| Synonyms | |
| SMILES | O=C(N[C@H](C1=CC=CC=C1)CC)C2=C(C(C3=CC=CC=C3)=NC4=CC=CC=C24)OCC(O)=O |
Biological Activity
| Description | SB 235375 is a selective antagonist of the human neurokinin-3 (hNK-3) receptor, developed through structural optimization of 2-phenyl-4-quinolinecarboxylic acid amide. It exhibits high affinity specifically for the hNK-3 receptor, showing significantly lower binding to hNK-1 and hNK-2 receptors. In vitro, SB 235375 effectively inhibits NK-3 receptor-mediated contraction and calcium mobilization. Additionally, in vivo studies reveal its capability to attenuate NK-3 receptor-driven responses through both oral and intravenous administration in animal models. This makes SB 235375 a valuable tool for research in neurokinin signaling and related physiological processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
