Product Data Sheet
DNK-333
Catalog No. A62113
DNK-333 is a potent dual antagonist of the NK1 and NK2 receptors, exhibiting IC50 values of 4.8 nM and 5.5 nM, respectively. This compound effectively inhibits Neurokinin A (NKA)-induced bronchoconstriction, making it a valuable tool for research on respiratory conditions such as asthma. Its balanced activity at both receptor sites allows for exploring therapeutic strategies targeting neurokinin signaling pathways.
Chemical Information
| Catalog Num | A62113 |
|---|---|
| M. Wt | 624.40 |
| Formula | C27H25Cl2F6N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 398507-81-8 |
| Synonyms | |
| SMILES | O=C(N([C@H](CC1=CC(Cl)=C(Cl)C=C1)/C=C/C(N[C@H]2C(NCCCC2)=O)=O)C)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3 |
Biological Activity
| Description | DNK-333 is a potent dual antagonist of the NK1 and NK2 receptors, exhibiting IC50 values of 4.8 nM and 5.5 nM, respectively. This compound effectively inhibits Neurokinin A (NKA)-induced bronchoconstriction, making it a valuable tool for research on respiratory conditions such as asthma. Its balanced activity at both receptor sites allows for exploring therapeutic strategies targeting neurokinin signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
