Product Data Sheet
Vestipitant
Catalog No. A62138
Vestipitant is a selective neurokinin-1 (NK1) receptor antagonist with a high binding affinity (pKi: 9.4, hNK1). This compound demonstrates significant hypnotic properties, effectively alleviating primary insomnia and other anxiety-related disorders. Its action includes the inhibition of substance P-mediated extracellular regulated kinase phosphorylation, showing potential applications in addressing conditions such as functional dyspnea, irritable bowel disease, gastroesophageal reflux disease, and tinnitus. Researchers may find vestipitant useful in studies related to anxiety, depression, and sleep disturbances.
Chemical Information
| Catalog Num | A62138 |
|---|---|
| M. Wt | 491.44 |
| Formula | C23H24F7N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 334476-46-9 |
| Synonyms | GW597599 |
| SMILES | C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)CNCC2)=O |
Biological Activity
| Description | Vestipitant is a selective neurokinin-1 (NK1) receptor antagonist with a high binding affinity (pKi: 9.4, hNK1). This compound demonstrates significant hypnotic properties, effectively alleviating primary insomnia and other anxiety-related disorders. Its action includes the inhibition of substance P-mediated extracellular regulated kinase phosphorylation, showing potential applications in addressing conditions such as functional dyspnea, irritable bowel disease, gastroesophageal reflux disease, and tinnitus. Researchers may find vestipitant useful in studies related to anxiety, depression, and sleep disturbances. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
