Product Data Sheet
ZM 253270
Catalog No. A62139
ZM 253270 is a non-peptide antagonist targeting the neurokinin-2 receptor (NK-2R). It competitively inhibits the binding of [3H]NKA to native or cloned hamster NK-2R, demonstrating high potency with a Ki value of 2 nM. In contrast, ZM 253270 exhibits reduced efficacy on cloned human NK-2R, with a 48-fold weaker inhibitory effect. This compound is valuable for research investigating the role of NK-2R in various physiological and pathological processes.
Chemical Information
| Catalog Num | A62139 |
|---|---|
| M. Wt | 471.94 |
| Formula | C22H26ClN7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 169340-04-9 |
| Synonyms | |
| SMILES | O=C(N1CCN(CC1)C2=NC(C(N(C(C)C)C3)=O)=C3C(NC4=CC=C(C=C4)Cl)=N2)/C(C)=N/O |
Biological Activity
| Description | ZM 253270 is a non-peptide antagonist targeting the neurokinin-2 receptor (NK-2R). It competitively inhibits the binding of [3H]NKA to native or cloned hamster NK-2R, demonstrating high potency with a Ki value of 2 nM. In contrast, ZM 253270 exhibits reduced efficacy on cloned human NK-2R, with a 48-fold weaker inhibitory effect. This compound is valuable for research investigating the role of NK-2R in various physiological and pathological processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
