Product Data Sheet
ZD6021
Catalog No. A62140
ZD6021 is a potent antagonist of the Neurokinin 1 (NK1) receptor, exhibiting a Ki value of 0.12 nM for NK1 and 0.62 nM for NK2. This compound has demonstrated significant biological activity by reducing plasma protein extravasation in guinea pigs induced by ASMSP, with an effective dose (ED50) of 0.5 mg/kg. Additionally, ZD6021 effectively mitigates NK2-mediated bronchoconstriction, showcasing an ED50 of 13 mg/kg. Its selective antagonism supports research applications in understanding neurogenic inflammation and respiratory conditions.
Chemical Information
| Catalog Num | A62140 |
|---|---|
| M. Wt | 632.64 |
| Formula | C35H35Cl2N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 255049-08-2 |
| Synonyms | |
| SMILES | O=C(N(C)C[C@@H](CCN1CCC(CC1)C2=CC=CC=C2[S@](C)=O)C3=CC=C(C(Cl)=C3)Cl)C4=C5C=CC=CC5=CC(C#N)=C4 |
Biological Activity
| Description | ZD6021 is a potent antagonist of the Neurokinin 1 (NK1) receptor, exhibiting a Ki value of 0.12 nM for NK1 and 0.62 nM for NK2. This compound has demonstrated significant biological activity by reducing plasma protein extravasation in guinea pigs induced by ASMSP, with an effective dose (ED50) of 0.5 mg/kg. Additionally, ZD6021 effectively mitigates NK2-mediated bronchoconstriction, showcasing an ED50 of 13 mg/kg. Its selective antagonism supports research applications in understanding neurogenic inflammation and respiratory conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
