Product Data Sheet
M871
Catalog No. A62190
M871 is a selective antagonist of the galanin receptor type 2 (GalR2), demonstrating a Ki value of 13.1 nM for GalR2, with significantly lower affinity for GalR1 and GalR3. This compound has been shown to reduce IgE production and the density of B cells in tissues, effectively alleviating allergic rhinitis in murine models. Additionally, M871 may impede nerve invasion in salivary adenoid cystic carcinoma and mitigate myocardial ischemia-reperfusion injury, making it a valuable tool for investigating GalR2-related conditions, including epilepsy and pain.
Chemical Information
| Catalog Num | A62190 |
|---|---|
| M. Wt | 2287.61 |
| Formula | C108H163N27O28 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 908844-75-7 |
| Synonyms | Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide |
| SMILES | C(=O)(N1[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)C)=O)CCC2)CCC1)[C@H]3N(C([C@H](CC4=CN=CN4)NC([C@@H](NC(=O)[C@H]5N(C(CNC([C@@H](NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=7C=8C(NC7)=CC=CC8)N)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CCC5)CCC(O)=O)=O)=O)CCC3 |
Biological Activity
| Description | M871 is a selective antagonist of the galanin receptor type 2 (GalR2), demonstrating a Ki value of 13.1 nM for GalR2, with significantly lower affinity for GalR1 and GalR3. This compound has been shown to reduce IgE production and the density of B cells in tissues, effectively alleviating allergic rhinitis in murine models. Additionally, M871 may impede nerve invasion in salivary adenoid cystic carcinoma and mitigate myocardial ischemia-reperfusion injury, making it a valuable tool for investigating GalR2-related conditions, including epilepsy and pain. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
