Product Data Sheet
Galantide
Catalog No. A62225
Galantide serves as a non-specific antagonist of galanin receptors, comprised of peptides derived from galanin and substance P. It effectively recognizes two distinct classes of galanin binding sites in the rat hypothalamus, with dissociation constants (KD) of less than 0.1 nM and approximately 6 nM. Galantide demonstrates dose-dependent antagonism (IC50 = 1.0 nM) of galanin-mediated inhibition on glucose-induced insulin secretion in mouse pancreatic islets. Additionally, it binds to a singular population of substance P receptors with a KD of around 40 nM, demonstrating its potential for investigating galanin signaling pathways and their physiological effects.
Chemical Information
| Catalog Num | A62225 |
|---|---|
| M. Wt | 2199.53 |
| Formula | C104H151N25O26S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 138579-66-5 |
| Synonyms | |
| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CN)C(C)O)C(N)=O |
Biological Activity
| Description | Galantide serves as a non-specific antagonist of galanin receptors, comprised of peptides derived from galanin and substance P. It effectively recognizes two distinct classes of galanin binding sites in the rat hypothalamus, with dissociation constants (KD) of less than 0.1 nM and approximately 6 nM. Galantide demonstrates dose-dependent antagonism (IC50 = 1.0 nM) of galanin-mediated inhibition on glucose-induced insulin secretion in mouse pancreatic islets. Additionally, it binds to a singular population of substance P receptors with a KD of around 40 nM, demonstrating its potential for investigating galanin signaling pathways and their physiological effects. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
