Product Data Sheet
GR231118
Catalog No. A62256
GR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions.
Chemical Information
| Catalog Num | A62256 |
|---|---|
| M. Wt | 2352.74 |
| Formula | C110H170N34O24 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 158859-98-4 |
| Synonyms | 1229U91; GW1229 |
| SMILES | O=C1N2[C@](C(=O)N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)CNC(=O)CC[C@H](NC([C@H]([C@H](CC)C)N)=O)C(=O)N5C(C(=O)N[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC7=CC=C(O)C=C7)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)CNC(=O)CC[C@@H]1NC([C@H]([C@H](CC)C)N)=O)(CCC5)[H])(CCC2)[H] |
Biological Activity
| Description | GR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
