Product Data Sheet
NPY Y2 antagonist 2
Catalog No. A62260
NPY Y2 Antagonist 2 is a selective inhibitor of the neuropeptide Y receptor Y2, exhibiting pKi values of 6.8 nM and 7.2 nM in human and rat brain tissues, respectively. This compound effectively blocks the NPY Y2-mediated negative feedback, leading to increased endogenous NPY release and enhanced activation of Y1 receptors. Its ability to penetrate the blood-brain barrier, along with moderate in vivo clearance and a favorable brain/plasma ratio, makes NPY Y2 Antagonist 2 a valuable tool for investigating mood disorders, alcohol withdrawal-related anxiety, and social anxiety linked to nicotine withdrawal.
Chemical Information
| Catalog Num | A62260 |
|---|---|
| M. Wt | 536.04 |
| Formula | C27H33ClF3N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1262495-12-4 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(C(Cl)=C1)N2CCC3(CN(CC3)CC4CC4)CC2)C(C5=NC=CC(=N5)C(F)(F)F)(C)C |
Biological Activity
| Description | NPY Y2 Antagonist 2 is a selective inhibitor of the neuropeptide Y receptor Y2, exhibiting pKi values of 6.8 nM and 7.2 nM in human and rat brain tissues, respectively. This compound effectively blocks the NPY Y2-mediated negative feedback, leading to increased endogenous NPY release and enhanced activation of Y1 receptors. Its ability to penetrate the blood-brain barrier, along with moderate in vivo clearance and a favorable brain/plasma ratio, makes NPY Y2 Antagonist 2 a valuable tool for investigating mood disorders, alcohol withdrawal-related anxiety, and social anxiety linked to nicotine withdrawal. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
