Product Data Sheet
BMS-986122
Catalog No. A62330
BMS-986122 is a selective positive allosteric modulator of the mu-opioid receptor (µ-OR) that enhances the activity of orthosteric agonists. This compound effectively increases β-arrestin recruitment, inhibits adenylyl cyclase, and activates G protein signaling pathways. BMS-986122 demonstrates the ability to potentiate DAMGO-mediated [35S]GTPγS binding in mouse brain membranes, making it a valuable tool for research in pain management and opioid pharmacology.
Chemical Information
| Catalog Num | A62330 |
|---|---|
| M. Wt | 448.78 |
| Formula | C16H15BrClNO3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 313669-88-4 |
| Synonyms | |
| SMILES | O=S(N1C(C2=CC=C(OC)C(Br)=C2)SCC1)(C3=CC=C(Cl)C=C3)=O |
Biological Activity
| Description | BMS-986122 is a selective positive allosteric modulator of the mu-opioid receptor (µ-OR) that enhances the activity of orthosteric agonists. This compound effectively increases β-arrestin recruitment, inhibits adenylyl cyclase, and activates G protein signaling pathways. BMS-986122 demonstrates the ability to potentiate DAMGO-mediated [35S]GTPγS binding in mouse brain membranes, making it a valuable tool for research in pain management and opioid pharmacology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
