Product Data Sheet
TAN-452
Catalog No. A62338
TAN-452 is a selective, orally active δ-opioid receptor antagonist, exhibiting a Ki of 0.47 nM and a Kb of 0.21 nM. This reagent also shows antagonistic properties toward μ-opioid receptors, with a Ki of 36.56 nM, and κ-opioid receptors, with a Ki of 5.31 nM. TAN-452 is designed to attenuate morphine-induced side effects while maintaining analgesic efficacy, making it valuable for research in pain management and opioid-related studies. Its low brain penetrability further supports peripheral applications, minimizing central nervous system interactions.
Chemical Information
| Catalog Num | A62338 |
|---|---|
| M. Wt | 486.56 |
| Formula | C29H30N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 892039-23-5 |
| Synonyms | |
| SMILES | O=C(C1=CC2=C(C=C1)C3=C([C@@](OC4=C(O)C=CC(C5)=C46)([H])[C@]76[C@@]([C@]5([H])N(CC8CC8)CC7)(O)C3)N2)OCC |
Biological Activity
| Description | TAN-452 is a selective, orally active δ-opioid receptor antagonist, exhibiting a Ki of 0.47 nM and a Kb of 0.21 nM. This reagent also shows antagonistic properties toward μ-opioid receptors, with a Ki of 36.56 nM, and κ-opioid receptors, with a Ki of 5.31 nM. TAN-452 is designed to attenuate morphine-induced side effects while maintaining analgesic efficacy, making it valuable for research in pain management and opioid-related studies. Its low brain penetrability further supports peripheral applications, minimizing central nervous system interactions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
