Product Data Sheet
Asimadoline hydrochloride
Catalog No. A62348
Asimadoline hydrochloride is a selective κ-opioid agonist that exhibits peripheral activity with IC50 values of 5.6 nM in guinea pig tissues and 1.2 nM in human recombinant assays. This compound has limited blood-brain barrier permeability, making it suitable for targeting peripheral anti-inflammatory pathways. Asimadoline hydrochloride has demonstrated effectiveness in alleviating allodynia in diabetic rat models and offers potential therapeutic applications in the treatment of irritable bowel syndrome (IBS).
Chemical Information
| Catalog Num | A62348 |
|---|---|
| M. Wt | 451.00 |
| Formula | C27H31ClN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 185951-07-9 |
| Synonyms | EMD-61753 hydrochloride |
| SMILES | O[C@H]1CCN(C1)C[C@H](C2=CC=CC=C2)N(C)C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O.[H]Cl |
Biological Activity
| Description | Asimadoline hydrochloride is a selective κ-opioid agonist that exhibits peripheral activity with IC50 values of 5.6 nM in guinea pig tissues and 1.2 nM in human recombinant assays. This compound has limited blood-brain barrier permeability, making it suitable for targeting peripheral anti-inflammatory pathways. Asimadoline hydrochloride has demonstrated effectiveness in alleviating allodynia in diabetic rat models and offers potential therapeutic applications in the treatment of irritable bowel syndrome (IBS). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
