Product Data Sheet
Loperamide
Catalog No. A62358
Loperamide is a selective μ opioid receptor agonist with Ki values of 3, 48, and 1156 nM for μ, δ, and κ opioid receptors, respectively. It demonstrates significant antinociceptive and antihyperalgesic properties, along with peripheral selectivity that enhances fluid, electrolyte, and glucose absorption. Loperamide effectively mitigates intestinal secretion induced by PGE2 and cholera toxin while reducing intestinal motility. This compound is applicable in research focused on inflammatory pain and chronic diarrhea.
Chemical Information
| Catalog Num | A62358 |
|---|---|
| M. Wt | 477.04 |
| Formula | C29H33ClN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 53179-11-6 |
| Synonyms | ADL 2-1294 |
| SMILES | O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)N(C)C |
Biological Activity
| Description | Loperamide is a selective μ opioid receptor agonist with Ki values of 3, 48, and 1156 nM for μ, δ, and κ opioid receptors, respectively. It demonstrates significant antinociceptive and antihyperalgesic properties, along with peripheral selectivity that enhances fluid, electrolyte, and glucose absorption. Loperamide effectively mitigates intestinal secretion induced by PGE2 and cholera toxin while reducing intestinal motility. This compound is applicable in research focused on inflammatory pain and chronic diarrhea. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
