Product Data Sheet
R-6890
Catalog No. A62372
R-6890 is an opioid receptor ligand that acts as a selective antagonist, displaying significant binding affinity to rat opioid receptors with an IC50 of 4.6 nM in Tris buffer at pH 7.4. Its ability to displace radiolabeled opioids from receptors is notable, although its binding affinity is influenced by environmental conditions, particularly sodium chloride concentrations. R-6890 effectively crosses the blood-brain barrier and demonstrates analgesic properties in the warm water-induced tail-flick reflex assay in male Wistar rats, making it a valuable tool for research into pain mechanisms and opioid pharmacology.
Chemical Information
| Catalog Num | A62372 |
|---|---|
| M. Wt | 369.89 |
| Formula | C21H24ClN3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3222-88-6 |
| Synonyms | |
| SMILES | O=C1NCN(C12CCN(C(C)C3=CC=C(C=C3)Cl)CC2)C4=CC=CC=C4 |
Biological Activity
| Description | R-6890 is an opioid receptor ligand that acts as a selective antagonist, displaying significant binding affinity to rat opioid receptors with an IC50 of 4.6 nM in Tris buffer at pH 7.4. Its ability to displace radiolabeled opioids from receptors is notable, although its binding affinity is influenced by environmental conditions, particularly sodium chloride concentrations. R-6890 effectively crosses the blood-brain barrier and demonstrates analgesic properties in the warm water-induced tail-flick reflex assay in male Wistar rats, making it a valuable tool for research into pain mechanisms and opioid pharmacology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
