Product Data Sheet
Ac-RYYRIK-NH2
Catalog No. A62534
Ac-RYYRIK-NH2 serves as a potent partial agonist of the ORL1 receptor, exhibiting a dissociation constant (Kd) of 1.5 nM in CHO cell models. This compound mimics the action of endogenous ligands, facilitating research into ORL1-related pathways. Additionally, it acts as a specific antagonist for G protein activation, competitively inhibiting [35S]-GTPgS binding stimulated by nociceptin/orphanin FQ in rat brain membranes and sections. Applications include studies of pain modulation, neuropharmacology, and the underlying mechanisms of ORL1 receptor signaling.
Chemical Information
| Catalog Num | A62534 |
|---|---|
| M. Wt | 939.11 |
| Formula | C44H70N14O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 200959-48-4 |
| Synonyms | |
| SMILES | [C@@H](CC1=CC=C(O)C=C1)(NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCCNC(=N)N)NC(C)=O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O |
Biological Activity
| Description | Ac-RYYRIK-NH2 serves as a potent partial agonist of the ORL1 receptor, exhibiting a dissociation constant (Kd) of 1.5 nM in CHO cell models. This compound mimics the action of endogenous ligands, facilitating research into ORL1-related pathways. Additionally, it acts as a specific antagonist for G protein activation, competitively inhibiting [35S]-GTPgS binding stimulated by nociceptin/orphanin FQ in rat brain membranes and sections. Applications include studies of pain modulation, neuropharmacology, and the underlying mechanisms of ORL1 receptor signaling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
