Product Data Sheet
Methocinnamox
Catalog No. A62538
Methocinnamox is a selective and long-acting μ-opioid receptor (MOR) antagonist with a Ki of 0.6 nM. It binds non-covalently to the orthosteric site of the MOR in a pseudo-irreversible manner, leading to sustained receptor blockade until new receptors are synthesized. Additionally, Methocinnamox serves as a reversible antagonist at both kappa-opioid (KOR) and delta-opioid receptors (DOR), with Ki values of 4.9 nM and 2.2 nM, respectively, without exhibiting intrinsic agonist activity. This compound is applicable in research focused on opioid overdose reversal and addiction prevention.
Chemical Information
| Catalog Num | A62538 |
|---|---|
| M. Wt | 484.59 |
| Formula | C30H32N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 117339-76-1 |
| Synonyms | M-CAM |
| SMILES | O=C(CC1)[C@]([C@@](C2=C(C[C@H]3N4CC5CC5)C=C6)(CC4)[C@@]13NC(/C=C/C7=CC=C(C)C=C7)=O)([H])OC2=C6O |
Biological Activity
| Description | Methocinnamox is a selective and long-acting μ-opioid receptor (MOR) antagonist with a Ki of 0.6 nM. It binds non-covalently to the orthosteric site of the MOR in a pseudo-irreversible manner, leading to sustained receptor blockade until new receptors are synthesized. Additionally, Methocinnamox serves as a reversible antagonist at both kappa-opioid (KOR) and delta-opioid receptors (DOR), with Ki values of 4.9 nM and 2.2 nM, respectively, without exhibiting intrinsic agonist activity. This compound is applicable in research focused on opioid overdose reversal and addiction prevention. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
