Product Data Sheet
MOR antagonist 2 hydrochloride
Catalog No. A62556
MOR Antagonist 2 Hydrochloride is a selective μ-opioid receptor (MOR) antagonist that effectively penetrates the blood-brain barrier, exhibiting an IC50 of 28.37 nM and a Ki value of 0.18 nM. This compound stabilizes the inactive state of MOR, thereby reducing receptor activation. It has demonstrated efficacy in antagonizing analgesic effects in the mouse warm-water tail-flick test and shows a reduced incidence of withdrawal symptoms in mice subjected to opioid withdrawal. MOR Antagonist 2 Hydrochloride is valuable for research into opioid use disorder and related therapeutic applications.
Chemical Information
| Catalog Num | A62556 |
|---|---|
| M. Wt | 523.02 |
| Formula | C28H31ClN4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3075862-29-9 |
| Synonyms | |
| SMILES | O[C@]12[C@@H]3N(CC4CC4)CC[C@@]15C6=C(C=CC(O)=C6O[C@H]5[C@H](CC2)NC(C7=NC=CC8=C7NC=C8)=O)C3.Cl |
Biological Activity
| Description | MOR Antagonist 2 Hydrochloride is a selective μ-opioid receptor (MOR) antagonist that effectively penetrates the blood-brain barrier, exhibiting an IC50 of 28.37 nM and a Ki value of 0.18 nM. This compound stabilizes the inactive state of MOR, thereby reducing receptor activation. It has demonstrated efficacy in antagonizing analgesic effects in the mouse warm-water tail-flick test and shows a reduced incidence of withdrawal symptoms in mice subjected to opioid withdrawal. MOR Antagonist 2 Hydrochloride is valuable for research into opioid use disorder and related therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
