Product Data Sheet
TAN-67
Catalog No. A62566
TAN-67 is a non-peptidic agonist of the delta-opioid receptor, demonstrating significant antinociceptive activity in both diabetic and non-diabetic mouse models. It effectively reduces acetic acid-induced abdominal constrictions in a dose-dependent manner, exhibiting a stronger response in diabetic mice. The analgesic properties of TAN-67 are primarily mediated through the activation of delta 1-opioid receptors, as evidenced by the pronounced antagonism when a selective delta 1-opioid receptor antagonist is administered. This compound is useful for research into pain mechanisms and the potential therapeutic applications of delta-opioid receptor modulation.
Chemical Information
| Catalog Num | A62566 |
|---|---|
| M. Wt | 344.45 |
| Formula | C23H24N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 148545-09-9 |
| Synonyms | SB-205607 |
| SMILES | OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1 |
Biological Activity
| Description | TAN-67 is a non-peptidic agonist of the delta-opioid receptor, demonstrating significant antinociceptive activity in both diabetic and non-diabetic mouse models. It effectively reduces acetic acid-induced abdominal constrictions in a dose-dependent manner, exhibiting a stronger response in diabetic mice. The analgesic properties of TAN-67 are primarily mediated through the activation of delta 1-opioid receptors, as evidenced by the pronounced antagonism when a selective delta 1-opioid receptor antagonist is administered. This compound is useful for research into pain mechanisms and the potential therapeutic applications of delta-opioid receptor modulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
