Product Data Sheet
SHR0687
Catalog No. A62570
SHR0687 is a selective tetrapeptide kappa opioid receptor (KOR) agonist, exhibiting an EC50 of 0.53 pM. This compound demonstrates high potency and selectivity for KOR over mu opioid receptors (MOR) and delta opioid receptors (DOR), with minimal penetration of the blood-brain barrier. SHR0687 selectively activates KOR, which may enable the modulation of neurological pathways while minimizing central nervous system side effects. It is suitable for research applications focused on pain modulation and the exploration of KOR-related mechanisms.
Chemical Information
| Catalog Num | A62570 |
|---|---|
| M. Wt | 720.94 |
| Formula | C39H60N8O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2168573-03-1 |
| Synonyms | |
| SMILES | C[C@H](C1=CC=CC=C1)CNCC(N[C@H](CC2=CC=CC=C2)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N3CCC(CC3)NC(NC)=O)=O)=O)=O)=O |
Biological Activity
| Description | SHR0687 is a selective tetrapeptide kappa opioid receptor (KOR) agonist, exhibiting an EC50 of 0.53 pM. This compound demonstrates high potency and selectivity for KOR over mu opioid receptors (MOR) and delta opioid receptors (DOR), with minimal penetration of the blood-brain barrier. SHR0687 selectively activates KOR, which may enable the modulation of neurological pathways while minimizing central nervous system side effects. It is suitable for research applications focused on pain modulation and the exploration of KOR-related mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
